Treatment with MDL 72527 Ameliorated Clinical Symptoms, Retinal Ganglion Cell Loss, Optic Nerve Inflammation, and Improved Visual Acuity in an Experimental Model of Multiple Sclerosis

Multiple Sclerosis (MS) is a highly disabling neurological disease characterized by inflammation, neuronal damage, and demyelination.Vision impairment is one of the major clinical features of MS.Previous studies from our lab have shown that MDL 72527, a pharmacological inhibitor of spermine oxidase (SMOX), is protective against neurodegeneration an

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University Transformation Model: Theory and Practice

This article considers the Lip Balms identification of the VUCA-world influence as a modern reality on the transformation of University on the example of Norilsk State Industrial Institute, its internal development space.The research relies on various methods: case-method, foresight, design method, depth interviews with the most important stakehold

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Robustifying and simplifying high-dimensional regression with applications to yearly stock return and telematics data

Abstract The availability of many variables with predictive power Fly Rugs makes their selection in a regression context difficult.This study considers robust and understandable low-dimensional estimators as building blocks to improve overall predictive power by optimally combining these building blocks.Our new algorithm is based on generalized cro

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